DynoChem
Delivering productivity and QbD in process development
Historically, there has been an over-reliance on experimentation and trial and error as a means of process development and scale-up. Given the impact on development timescales and costs, both manufacturers and regulators are now seeking better solutions in this area.
DynoChem is the first and only software tool that genuinely supports the development of process understanding at both a project & corporate level. We provide a framework in which both chemists and engineers can apply the scientific method, using modeling and simulation alongside experiments, developing more robust processes quickly and implementing quality by design (QbD).
Features
- Model Library of 160 standard templates for API synthesis operations.
- Applicable to all work-up and isolation operations (not just reactions), from a single software environment.
- Easy handling of multi-phase / heterogeneous systems, phase changes, phase transfers.
- Lab reactor templates for equipment from all major vendors (e.g. Argonaut Endeavor, Omnical CRC90, Mettler-Toledo MultiMax, RC1, HEL AutoMate, Simular).
- Ability to use shortcut or fuller scale-up workflows.
- Easily fit parameters to multiple experiments, at different temperatures, with multiple responses.
- Tight integration with everyday MS Office tools, especially Excel and Word.
- Link to Batch Plus®, contains DIPPR for physical properties.
- Self-training module to facilitate uptake by new users (30% of users are chemists).
- User support from reaction engineers with experience of hundreds of reaction steps.
- Advice on experimental design, methods and data requirements and data interpretation.
- Responsive development programme with regular upgrades and addition of models to website Users Area.
A fully functional trial copy of DynoChem is available on request.
DynoChem users and applications
Process development chemists
Reduce number of experiments, amount of time and material required for reaction development and optimisation. Create models directly from your data, get a feel for reaction profiles and effects of equivalents and temperature. Fit parameters, distinguish reaction mechanisms and find optimum conditions faster than with custom spreadsheets or ODE solvers.
Safety labs
Interpret Qr, IR, gas evolution data; predict safe feed times for dosing-controlled reactions from Qr profiles and gas evolution rates; find conditions to make reactions dosing-controlled; include DynoChem report as appendix in safety report.
Chemical development engineers
Identify yield-limiting steps, anticipate and optimise process robustness on scale; take account of both chemical and equipment-related factors.
Plant/Technical Operations engineers
Perform process fit, heat transfer and agitation calculations; determine distillation pressures, temperatures, solvent requirements and times; reduce drying times; use models from earlier development for smooth technology transfer.
Plant chemists
Anticipate 'spoilers' due to equipment limitations; use lab data to assist with validation, troubleshooting and optimisation projects.
Crystallisation specialists
Interpret IR and FBRM data; convert between CLD and CSD; assess vessels and mixing; simulate all types of crystallisation.