Safe, Convenient ortho-Claisen Thermal Rearrangement Using a Flow Reactor
Presents a process that utilized a tube reactor to make 80 g of an early phase intermediate in a short time while mitigating the potential chemistry hazards. Continuous. PFR.
Unit Operation: Reaction
Objective: Design
Company: Lilly
Source: Org. Process Res. Dev., 2011, 15 (6), pp 1428–1432
Authors: Mario Barberis (Lilly), María González-Esguevillas (Lilly), Martin D. Johnson (Lilly), Jeff Niemeier (Lilly), Juan A. Rincón (Lilly), Wei-Ming Sun (Lilly)
Publish Date: 04-Apr-2012
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