Optimization of the Manufacturing Route to PF-610355 ( 1 ): Synthesis of Intermediate 5
Tertiary carbinamine 5 is an isolated intermediate in the synthesis of a novel, inhaled β-2 adrenoreceptor agonist PF-610355. Process development for the key amide-formation and Ritter reactions, together with reaction understanding studies are discussed.
Unit Operation: Reaction
Objective: Design
Company: Pfizer
Source: Org. Process Res. Dev., 2013, 17 (2), pp 193–201
Authors: Stéphane Content (Pfizer), Julian D. Smith (Pfizer), Thomas Dupont (Pfizer), Steven J. R. Twiddle (Pfizer), Nicola M. Fédou (Pfizer)
Publish Date: 05-Feb-2013
Copyright © 2018 Scale-up Systems Ltd. | DynoChem Software and Development Services for the Pharma Industry | Privacy | Cookies | Contact