Modeling-based Development of an Enantioselective Hydrogenation Reaction of a Sitagliptine Intermediate
This work presents a quality by design (QbD) driven approach to experiments and DynoChem modeling that was effective in obtaining enhanced process knowledge and defining a design space.
Unit Operation: Hydrogenation
Objective: Design
Company: PLIVA
Source: Chem. Biochem. Eng. Q., 28 (1) 1–11 (2014)
Authors: F. Jovic (PLIVA), E. Marcelic (PLIVA), E. Mestrovic (PLIVA), I. Nezic (PLIVA), I. Sostaric (PLIVA), S. Zrncevicb (PLIVA)
Publish Date: 09-Sep-2013
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