Model-Based Scale-up and Design Space Determination for a Batch Reactive Distillation with a Dean–Stark Trap
A detailed model of a reactive distillation was developed with water removed via a Dean-Stark trap (liquid-liquid separator) for calculation of Design Space (QbD). Common cause variability and model parameter uncertainty were also accounted for.
Unit Operation: Distillation
Objective: QbD
Company: Lilly
Source: Organic Process Research and Development 2013
Authors: Isabel Figueroa (Lilly), Shankar Vaidyaraman (Lilly), Shekhar K. Viswanath (Lilly)
Publish Date: 22-Jul-2013
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