Use of Modeling and Process Analytical Technologies in the Design of a Catalytic Amination Reaction: Understanding Oxygen Sensitivity at the Lab and Manufacturing Scales
An experimental mechanistic study was undertaken to understand the effect of oxygen on the reaction. A reactor model was then used to control dissolved oxygen levels on scale.
Unit Operation: Reaction
Objective: Scale-Up
Company: Lilly
Source: Organic Process Research and Development 2014
Authors: Jonas Y. Buser (Lilly), Alison N. Campbell (Lilly), Jared W. Fennell (Lilly), Neil J. Kallman (Lilly), Thomas M. Koenig (Lilly), Jeremy M. Merritt (Lilly), Hossam Moursy (Lilly), Mark Pietz (Lilly), Norma Scully (Lilly), Utpal Singh (Lilly)
Publish Date: 28-Nov-2013
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