Application of Kinetic Modeling and Competitive Solvent Hydrolysis in the Development of a Highly Selective Hydrolysis of a Nitrile to an Amide
A combination of mechanism-guided experimentation and kinetic modeling was used to optimise a reaction and eliminate the major reaction impurity. The model was then used to check process robustness on a 90 kg scale.
Unit Operation: Reaction
Objective: QbD, Scale-Up
Company: Lilly
Source: Organic Process Research and Development 2014
Authors: Jeff Niemeier (Lilly), Roger R. Rothhaar (Lilly), Jeffrey T. Vicenzi (Lilly), John A. Werner (Lilly)
Publish Date: 16-Jul-2014
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