Mitigating the Risk of Coprecipitation of Pinacol during Isolation from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Boron Pinacol Esters: Use of Modeling for Process Design
A Quality by Design (QbD) approach was used to illustrate the control strategy and provide a maximally flexible process for manufacturing to maintain high purity of the intermediate.
Unit Operation: Crystallization, Distillation, Reaction
Objective: Design, Kinetics, Modeling, QbD
Company: Lilly
Source: Organic Process Research and Development 2015
Authors: Marimuthu Andiappan (Lilly), Douglas Kjell (Lilly), Jeremy M. Merritt (Lilly), Mark Pietz (Lilly), Rachel Richey (Lilly), Kevin Sullivan (Lilly)
Publish Date: 21-Dec-2015
Copyright © 2019 Scale-up Systems Ltd. | DynoChem Software and Development Services for the Pharma Industry | Privacy | Cookies | Contact