Mitigating the risk of Coprecipitation of Pinacol during Isolation from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Boron Pinacol Esters: Use of Modeling for Process Design
How Lilly used process modeling to develop an effective control strategy to mitigate the unexpected precipitation of pinacol while telescoping a class of reactions.
Unit Operation: Crystallization, Distillation
Objective: Design, Kinetics, Optimization
Company: Lilly
Source: DynoChem Guest Webinar Series 2016
Authors: Marimuthu Andiappan (Lilly), Jeremy M. Merritt (Lilly)
Publish Date: 08-Jun-2016
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