Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated SNAr Coupling
This manuscript focuses on the SNAr coupling between aminopyridine 3 and chloropyrimidine 7.
Unit Operation: Reaction
Objective: QbD, Scale-Up
Company: Pfizer
Source: Org. Process Res. Dev., 2016, 20 (7), pp 1191–1202
Authors: Jon Blunt (Pfizer), John Draper (Pfizer), Shengquan Duan (Pfizer), Nathan D. Ide (Pfizer), Fangming Kong (Pfizer), Kyle Leeman (Pfizer), Denis Lynch (Pfizer), Mark Maloney (Pfizer), Marie McAuliffe (Pfizer), Maria O’Sullivan (Pfizer), Mark Olivier (Pfizer), Hahdi H. Perfect (Pfizer), David Place (Pfizer), Kristin E. Price Wiglesworth (Pfizer), Karen Sutherland (Pfizer), Ke Wang (Pfizer)
Publish Date: 12-May-2016
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