Investigation of Variable Impurity Profile from a Mitsunobu Reaction Using Insights from Kinetic Modeling, Multi-Phase Interactions, and Computational Fluid Dynamics
A drug substance intermediate synthesis involving a Mitsunobu coupling reaction using triphenylphosphine and diisopropyl azodicarboxylate was investigated to understand the variable levels of an impurity.
Unit Operation: Reaction
Objective: Kinetics, QbD
Company: AbbVie
Source: Ind. Eng. Chem. Res., 2016, 55 (17), pp 4867–4877
Authors: Shailendra V. Bordawekar (AbbVie), Samrat Mukherjee (AbbVie), Nandkishor Nere (AbbVie)
Publish Date: 11-Apr-2016
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