Appearance of a New Hydrated Form during Development: A Case Study in Process and Solid-State Optimization
The appearance of a new solid phase during the development of a small molecule presents significant challenges for optimizing form control during crystallization and mitigating potential delays in development timelines.
Unit Operation: Crystallization
Objective: Characterization, Design
Company: Amgen
Source: Org. Process Res. Dev., 2015, 19 (12), pp 1842–1848
Authors: Sheng Cui (Amgen), Karl B Hansen (Amgen), Henry Morrison (Amgen), Karthik Nagapudi (Amgen), Bin P. Quan (Amgen), Shawn D. Walker (Amgen)
Publish Date: 26-Jun-2015
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