Development of a Continuous Plug Flow Process for Preparation of a Key Intermediate for Brivanib Alaninate
A continuous (PFR) process was developed using both Qr and composition data to mitigate the potential thermal runaway and allow for safer scale-up.
Unit Operation: Reaction
Objective: Design, Scale-Up
Company: BMS
Source: Org. Process Res. Dev., 2014, 18 (11), pp 1492–1502
Authors: Steve Chan (BMS), Mourad Hamedi (BMS), Thomas Laporte (BMS), Paul Lobben (BMS), Jale Müslehiddinoglu (BMS), Lori Spangler (BMS), Steve S. Y. Wang (BMS)
Publish Date: 14-Oct-2014
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