Application of Kinetic Modeling and Competitive Solvent Hydrolysis in the Development of a Highly Selective Hydrolysis of a Nitrile to an Amide
A combination of mechanism-guided experimentation and kinetic modeling was used to develop a mild, selective, and robust hydroxide-promoted process for conversion of a nitrile to an amide.
Unit Operation: Reaction
Objective: Design, Kinetics
Company: Lilly
Source: Org. Process Res. Dev., 2014, 18 (3), pp 410–416
Authors: Jeff Niemeier (Lilly), Roger R. Rothhaar (Lilly), Jeffrey T. Vicenzi (Lilly), John A. Werner (Lilly)
Publish Date: 11-Feb-2014
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