Development of Flow Processes for the Syntheses of N-Aryl Pyrazoles and Diethyl Cyclopropane-cis-1,2-dicarboxylate
N-Aryl pyrazoles were prepared from anilines in a three step telescoped approach. An aniline was diazotized to give the diazonium fluoroborate, followed by reduction with tin(II) chloride to give the corresponding hydrazine.
Unit Operation: Reaction
Objective: Design
Company: Pfizer
Source: Managing Hazardous Reactions and Compounds in Process Chemistry Chapter 14, pp 383–402
Authors: Steven Guinness (Pfizer), Bryan Li (Pfizer)
Publish Date: 20-Nov-2014
Copyright © 2018 Scale-up Systems Ltd. | DynoChem Software and Development Services for the Pharma Industry | Privacy | Cookies | Contact