Development of a Leuckart-Wallach Reaction in Flow for the Synthesis of Abemaciclib
The development of a route for a key building block in the synthesis of abemaciclib is described. The route proceeds through a Leuckart–Wallach reductive amination in flow followed by an Ullmann amination with aqueous ammonia. PFR.
Unit Operation: Reaction
Objective: Kinetics
Company: Lilly
Source: Org. Process Res. Dev.
Authors: Michael O Frederick (Lilly), Michio Kida (Lilly), Douglas Kjell (Lilly), Toshiyasu Matsuo (Lilly), Mark Pietz (Lilly), Rachel Richey (Lilly), Gregg A. Tharp (Lilly), Taichiro Touge (Lilly), Naota Yokoyama (Lilly)
Publish Date: 16-Aug-2017
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