Publication
Optimization of the Manufacturing Route to PF-610355 (1): Synthesis of Intermediate 5
Tertiary carbinamine 5 is an isolated intermediate in the synthesis of a novel, inhaled β-2 adrenoreceptor agonist PF-610355. Process development for the key amide-formation and Ritter reactions, together with reaction understanding studies are discussed.
Unit Operation: Reaction
Objective: Optimization
Company: Pfizer
Source: Org. Process Res. Dev., 2013, 17 (2), pp 193–201
Authors: Stéphane Content (Pfizer), Thomas Dupont (Pfizer), Nicolas M. Fédou (Pfizer), Julian D. Smith (Pfizer), Steven J. R. Twiddle (Pfizer)
Publish Date: 05-Feb-2013
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