N,N′-Carbonyldiimidazole-Mediated Amide Coupling: Significant Rate Enhancement Achieved by Acid Catalysis with Imidazole·HCl
Over a series of 10 aromatic amines we show the rate of CDI mediated amidation to be significantly enhanced upon introduction of imidazole·HCl as a proton source for acid catalysis.
Unit Operation: Reaction
Objective: Kinetics
Company: AstraZeneca
Source: Org. Process Res. Dev., 2009, 13 (1), pp 106–113
Authors: Julian G K Chaffey (AstraZeneca), John P Gilday (AstraZeneca), Philip A Hopes (AstraZeneca), Emily K Woodman (AstraZeneca)
Publish Date: 05-Dec-2008
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