Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement
A convergent, robust, and concise synthesis of a developmental CCR1 antagonist is described using continuous flow technology. In the first approach, following an expeditious SNAr sequence for cyclopropane introduction, a safe, continuous flow ...
Unit Operation: Reaction
Objective: Kinetics
Company: Boehringer Ingelheim
Source: Green Chem., 2017,19, 1454-1461
Authors: Jason Brazzillo (Boehringer Ingelheim), Frederic G. Buono (Boehringer Ingelheim), J. C. Chung (Boehringer Ingelheim), Heewon Lee (Boehringer Ingelheim), Ning Li (Boehringer Ingelheim), Jon C. Lorenz (Boehringer Ingelheim), Irungu K. Luvaga (Boehringer Ingelheim), Maurice A. Marsini (Boehringer Ingelheim), Bikshandarkoil A. Narayanan (Boehringer Ingelheim), Laurence J. Nummy (Boehringer Ingelheim), Jonathan T. Reeves (Boehringer Ingelheim), Frank Roschangar (Boehringer Ingelheim), Max Sarvestani (Boehringer Ingelheim), Chris H. Senanayake (Boehringer Ingelheim), Kanwar Sidhu (Boehringer Ingelheim), Jinhua J. Song (Boehringer Ingelheim), Zhulin Tan (Boehringer Ingelheim), Xudong Wei (Boehringer Ingelheim), Bing-Shiou Yang (Boehringer Ingelheim), Nathan K. Yeea (Boehringer Ingelheim), Yongda Zhang (Boehringer Ingelheim)
Publish Date: 03-Jan-2017
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