Publication
Mechanistic investigation of a Ru-catalyzed direct asymmetric reductive amination reaction for a batch or continuous process scale-up: an industrial perspective
A comprehensive assessment of a Ru-catalyzed direct asymmetric reductive amination (DARA) reaction for producing an intermediate for an active pharmaceutical ingredient (API) was carried out. PFR.
Unit Operation: Process
Objective: Optimization
Company: Lilly, Takasago
Source: React. Chem. Eng., 2017, Advance Article
Authors: Shajuddin Changi (Lilly), Matthew C. Embry (Lilly), Martin D. Johnson (Lilly), Carla V. Luciani (Lilly), Eric D. Moher (Lilly), Hikaru Nakajima (Takasago), Sze Wing Wong (Lilly), Tetsuya Yamamoto (Takasago), Tohru Yokozawa (Takasago)
Publish Date: 08-Aug-2017
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