High-Throughput Automated Design of Experiment (DoE) and Kinetic Modeling to Aid in Process Development of an API
A Design of Experiment (DoE) and kinetic screening study was carried out using an automated reaction screening platform, and as a case study, an early stage in the synthesis of a late phase developmental candidate was investigated.
Unit Operation: Process
Objective: DoE, Kinetics, Modeling
Company: GSK, Unchained Labs
Source: Org. Process Res. Dev., 2018, 22 (1), pp 54–61
Authors: Andrew DiPietro (GSK), Neil Hodnett (GSK), Christopher Nunn (GSK), Pu Sun (Unchained Labs), Kenneth M. Wells (GSK)
Publish Date: 14-Dec-2017
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