Accelerating Bioprocess Development
Dynochem Biologics is a set of process development and scale-up tools for upstream (USP), downstream (DSP) and fill/finish processes.
Mixing calculation tools help scale from small scale reactors such as ambr™ 15, shake flasks and rocked / wave bags to large STRs, and establish equivalence in terms of mixing. Bioreactor models support prediction of glucose and DO levels, pH and titer at each scale.
Downstream capabilities include models for disk-stack centrifugation, depth filtration, virus inactivation, TFF and diafiltration. Fill/finish tools leverage predictions of Lyophilization (primary and secondary drying) in vials, including prevention of meltback / collapse.